Other Names: chlorophylline, clorofilina, sodium copper chlorophyll, sodium copper chlorophyllin

Chlorophyllin is a water-soluble derivative of chlorophyll and a very potent antioxidant that supports processes in the body which promote natural defenses that protect DNA from free radicals and oxidative stress. It is also helpful at supporting the body’s natural detoxification system, which helps the body maintain an optimal pH. High protein and acidic diets often cause too much acid to accumulate in the body, but chlorophyllin helps the detoxification system maintain pH stability. This supports energy levels, mental clarity and promotes clearer, healthier skin. Furthermore, the ability of chlorophyllin to supports detoxification processes helps the body protect itself from toxic chemicals before they even enter the bloodstream. Detoxification is also associated with enhanced circulatory function, which is essential for supporting good blood flow. All of these processes are useful towards maintaining optimal health.

Many people do not realize that environmental toxins include more than smoke and polluted air, but that damaging free radicals can come from certain cooked foods and even one’s own body. Antioxidants are the body’s main defense against these — they can support the body’s ability to protect DNA and counteract DNA damage.

In addition to being one of the world’s most potent antioxidants, chlorophyllin is also an “interceptor molecule”. This means that it becomes a signal for the immune system to activate processes that further protect DNA. Therefore, chlorophyllin is very useful at supporting optimal DNA health.

Studies on Chlorophyllin:

  1. Shaughnessy DT, Gangarosa LM, Schliebe B, Umbach DM, Xu Z, MacIntosh B, Knize MG, Matthews PP, Swank AE, Sandler RS, DeMarini DM, Taylor JA. Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One. 2011 Apr 25;6(4):e18707. doi: 10.1371/journal.pone.0018707.
  2. Dexin Guo and Roderick Dashwood. Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon. Carcinogenesis (1994) 15 (4): 763-766.
  3. Dexin Guo, Herman A.J. Schut, Cindy D. Davis, Elizabeth G. Snyderwine, George S. Bailey and Roderick H. Dashwood. Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis (1995) 16 (12): 2931-2937.
  4. Kyung-Joo Cho, Seung Hyun Han, Bu Yeo Kim, Seong-Gu Hwang, Kwang-Kyun Park, Kyu-Hwan Yang, An-Sik Chung. Chlorophyllin Suppression of Lipopolysaccharide-Induced Nitric Oxide Production in RAW 264.7 Cells. Toxicology and Applied Pharmacology; Volume 166, Issue 2, 15 July 2000, Pages 120–127.

Other research:

  1. Zhang M, Wang XF, Zhang FY, Wei M, Shi QH, Yang FJ, Li Y. [Effects of chlorophyllin-iron on osmotic adjustment and activities of antioxidantive enzymes in cucumber seedlings under suboptimal temperature]. [Article in Chinese] Ying Yong Sheng Tai Xue Bao. 2014 Dec;25(12):3527-32.
  2. Yang UJ, Park TS, Shim SM. Protective effect of chlorophyllin and lycopene from water spinach extract on cytotoxicity and oxidative stress induced by heavy metals in human hepatoma cells. J Toxicol Environ Health A. 2013;76(23):1307-15. doi: 10.1080/15287394.2013.851632.
  3. Boloor KK, Kamat JP, Devasagayam TP. Chlorophyllin as a protector of mitochondrial membranes against gamma-radiation and photosensitization. Toxicology. 2000 Nov 30;155(1-3):63-71.
  4. Keshava C, Keshava N, Whong WZ, Nath J, Ong TM. Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells. Teratog Carcinog Mutagen. 1997-1998;17(6):313-26.
  5. Kamat JP, Boloor KK, Devasagayam TP. Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochim Biophys Acta. 2000 Sep 27;1487(2-3):113-27.
  6. Kumar SS, Shankar B, Sainis KB. Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo. Biochim Biophys Acta. 2004 May 3;1672(2):100-11.
  7. Cho KJ, Han SH, Kim BY, Hwang SG, Park KK, Yang KH, Chung AS. Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Toxicol Appl Pharmacol. 2000 Jul 15;166(2):120-7.
  8. Ibrahim MA, Elbehairy AM, Ghoneim MA, Amer HA. Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene. Z Naturforsch C. 2007 Mar-Apr;62(3-4):215-22.
  9. Cruces MP, Pimentel E, Zimmering S. Evidence that low concentrations of chlorophyllin (CHLN) increase the genetic damage induced by gamma rays in somatic cells of Drosophila. Mutat Res. 2009 Sep-Oct;679(1-2):84-6. doi: 10.1016/j.mrgentox.2009.07.004. Epub 2009 Jul 16.
  10. Pimentel E, Cruces MP, Zimmering S. A study of the inhibition/promotion effects of sodium-copper chlorophyllin (SCC)-mediated mutagenesis in somatic cells of Drosophila. Mutat Res. 2011 May 18;722(1):52-5. doi: 10.1016/j.mrgentox.2011.03.001. Epub 2011 Mar 23.
  11. Shaughnessy DT, Gangarosa LM, Schliebe B, Umbach DM, Xu Z, MacIntosh B, Knize MG, Matthews PP, Swank AE, Sandler RS, DeMarini DM, Taylor JA. Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One. 2011 Apr 25;6(4):e18707. doi: 10.1371/journal.pone.0018707.
  12. Thiyagarajan P, Senthil Murugan R, Kavitha K, Anitha P, Prathiba D, Nagini S. Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis. Food Chem Toxicol. 2012 Mar;50(3-4):867-76. doi: 10.1016/j.fct.2011.12.019. Epub 2011 Dec 21.
  13. Grossi MR, Berni A, Pepe G, Filippi S, Mosesso P, Shivnani AA, Papeschi C, Natarajan AT, Palitti F. A comparative study of the anticlastogenic effects of chlorophyllin on N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) or 7,12-dimethylbenz (α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo. Toxicol Lett. 2012 Nov 15;214(3):235-42. doi: 10.1016/j.toxlet.2012.08.023. Epub 2012 Sep 15.
  14. A El-Ghor A, Noshy MM, Galal A, Mohamed HR. Normalization of nano-sized TiO2-induced clastogenicity, genotoxicity and mutagenicity by chlorophyllin administration in mice brain, liver, and bone marrow cells. Toxicol Sci. 2014 Nov;142(1):21-32. doi: 10.1093/toxsci/kfu157. Epub 2014 Aug 16.
  15. Domijan AM, Gajski G, Novak Jovanović I, Gerić M, Garaj-Vrhovac V. In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B(1) could be prevented by sodium copper chlorophyllin–implication to their genotoxic mechanism. Food Chem. 2015 Mar 1;170:455-62. doi: 10.1016/j.foodchem.2014.08.036. Epub 2014 Aug 19.
  16. Morales-Ramírez P, Vallarino-Kelly T, Rodríguez-Reyes R. Effect of chlorophyllin on gamma ray induced micronuclei in polychromatic erythrocytes of murine peripheral blood determined by the ABC strategy. Mutat Res. 1996 Feb;367(2):51-6.
  17. Kumar SS, Chaubey RC, Devasagayam TP, Priyadarsini KI, Chauhan PS. Inhibition of radiation-induced DNA damage in plasmid pBR322 by chlorophyllin and possible mechanism(s) of action. Mutat Res. 1999 Mar 10;425(1):71-9.
  18. Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis. 2005 Jul;26(7):1247-55. Epub 2005 Mar 17.
  19. Zhang Y, Guan L, Wang X, Wen T, Xing J, Zhao J. Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. Free Radic Res. 2008 Apr;42(4):362-71. doi: 10.1080/10715760801993076.
  20. Zhang YL, Guan L, Zhou PH, Mao LJ, Zhao ZM, Li SQ, Xu XX, Cong CC, Zhu MX, Zhao JY. [The protective effect of chlorophyllin against oxidative damage and its mechanism]. [Article in Chinese] Zhonghua Nei Ke Za Zhi. 2012 Jun;51(6):466-70.
  21. Suryavanshi S, Sharma D, Checker R, Thoh M, Gota V, Sandur SK, Sainis KB. Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis. Free Radic Biol Med. 2015 Apr 11;85:56-70. doi: 10.1016/j.freeradbiomed.2015.04.007. [Epub ahead of print]
  22. Sharma D, Kumar SS, Sainis KB. Antiapoptotic and immunomodulatory effects of chlorophyllin. Mol Immunol. 2007 Jan;44(4):347-59. Epub 2006 Apr 17.
  23. Nagai H, Nishiyori T, Daikoku M, Koda A. Immunopharmacological studies of sodium copper chlorphyllin (SCC). Jpn J Pharmacol. 1983 Aug;33(4):819-28.
  24. John K, Keshava C, Richardson DL, Weston A, Nath J. Immune response signatures of benzo{alpha}pyrene exposure in normal human mammary epithelial cells in the absence or presence of chlorophyllin. Cancer Genomics Proteomics. 2009 Jan-Feb;6(1):1-11.
  25. Singh A, Singh SP, Bamezai R. Modulatory influence of chlorophyllin on the mouse skin papillomagenesis and xenobiotic detoxication system. Carcinogenesis. 1996 Jul;17(7):1459-63.
  26. Clarenz P, Mönch H, Hölscher M, Zühlke V. Prolongation of skin graft survival by sodium-copper-chlorophyllin. Inhibition of the first- and second-set phenomenon. Eur Surg Res. 1976;8(2):148-55.

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