Other Names: Lentinula edodes

The shiitake mushroom, also known as Lentinula edodes, is an edible fungus native to East Asia — its immune supporting properties are backed by a number of studies. The shiitake mushroom extract is very helpful at supporting the immune system because, similar to the maitake mushroom extract, it is excellent sources of antioxidants. Furthermore, the shiitake mushroom also contains proteins, vitamins, minerals, fiber, carbohydrates and amino acids that promote cellular health. The body requires a rich source of healthy nutrients such as what is supplied by shiitake, so taking this mushroom extract can support overall health.

Research suggests that shiitake promotes adequate interferon levels in the body, a primary immune system regulator. By doing so, this mushroom extract has the ability to support healthy skin by supporting the immune system’s natural role in combating harmful invaders that can impair the skin. By supporting healthy levels of these proteins, shiitake mushrooms are extremely useful at helping the body protect itself from intruders.

The production of interferons from white blood cells also further activates immune system functions which include the activation of a specific form of white blood cells called macrophages that help remove harmful substances from the body. Therefore, shiitake’s ability to support optimal interferon levels is essential for strong immune system support. Shiitake has also been shown through research to help support proper detoxification and circulatory functions that are essential for supporting good blood flow as well as promote the body’s ability to naturally protect itself from free radicals and oxidative stress.

Studies on Shiitake Mushroom:

  1. Nianbai Fang, Qinglin Li, Shanggong Yu, Jianxiang Zhang, Ling He, Martin J.J. Ronis, and Thomas M. Badger. The Journal of Alternative and Complementary Medicine. March 2006, 12(2): 125-132. doi:10.1089/acm.2006.12.125.
  2. Zembron-Lacny A, Gajewski M, Naczk M, Siatkowski I. Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. J Physiol Pharmacol. 2013 Apr;64(2):249-54.
  3. Xiaoshuang Daia, Joy M. Stanilkaa, Cheryl A. Rowea, Elizabethe A. Estevesb, Carmelo Nieves Jr.a, Samuel J. Spaisera, Mary C. Christmanc, Bobbi Langkamp-Henkena & Susan S. Percivala.* Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. DOI:10.1080/07315724.2014.950391. 11 Apr 2015.
  4. Gaullier JM, Sleboda J, Øfjord ES, Ulvestad E, Nurminiemi M, Moe C, Tor A, Gudmundsen O. Supplementation with a soluble β-glucan exported from Shiitake medicinal mushroom, Lentinus edodes (Berk.) singer mycelium: a crossover, placebo-controlled study in healthy elderly. Int J Med Mushrooms. 2011;13(4):319-26.
  5. Mouruj A. Alaubydi and Reema M. Abed. The Usage of ß-glucan Extracted from Local Mushroom as Immunomodulator. Current Research Journal of Biological Sciences 3(5): 535-541, 2011.
  6. Terakawa N, Matsui Y, Satoi S, Yanagimoto H, Takahashi K, Yamamoto T, Yamao J, Takai S, Kwon AH, Kamiyama Y. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Nutr Cancer. 2008;60(5):643-51. doi: 10.1080/01635580801993280.
  7. Vaclav Vetvicka and Jana Vetvickova. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb; 2(2): 14.

Other research:

  1. Jiang T, Luo Z, Ying T. Fumigation with essential oils improves sensory quality and enhanced antioxidant ability of shiitake mushroom (Lentinus edodes). Food Chem. 2015 Apr 1;172:692-8. doi: 10.1016/j.foodchem.2014.09.130. Epub 2014 Sep 28.
  2. Zhang N, Chen H, Zhang Y, Ma L, Xu X. Comparative studies on chemical parameters and antioxidant properties of stipes and caps of shiitake mushroom as affected by different drying methods. J Sci Food Agric. 2013 Sep;93(12):3107-13. doi: 10.1002/jsfa.6151. Epub 2013 May 8.
  3. Carneiro AA, Ferreira IC, Dueñas M, Barros L, da Silva R, Gomes E, Santos-Buelga C. Chemical composition and antioxidant activity of dried powder formulations of Agaricus blazei and Lentinus edodes. Food Chem. 2013 Jun 15;138(4):2168-73. doi: 10.1016/j.foodchem.2012.12.036. Epub 2012 Dec 29.
  4. Reis FS, Martins A, Barros L, Ferreira IC. Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: a comparative study between in vivo and in vitro samples. Food Chem Toxicol. 2012 May;50(5):1201-7. doi: 10.1016/j.fct.2012.02.013. Epub 2012 Feb 18.
  5. Huang W, Kim JS, Chung HY. Antioxidant activity and total phenolic content in shiitake mycelial exudates. Nat Prod Commun. 2011 Jun;6(6):845-50.
  6. Turło J, Gutkowska B, Herold F. Effect of selenium enrichment on antioxidant activities and chemical composition of Lentinula edodes (Berk.) Pegl. mycelial extracts. Food Chem Toxicol. 2010 Apr;48(4):1085-91. doi: 10.1016/j.fct.2010.01.030. Epub 2010 Feb 4.
  7. Wu XJ, Hansen C. Antioxidant capacity, phenolic content, and polysaccharide content of Lentinus edodes grown in whey permeate-based submerged culture. J Food Sci. 2008 Jan;73(1):M1-8. doi: 10.1111/j.1750-3841.2007.00595.x.
  8. Zheng R, Jie S, Hanchuan D, Moucheng W. Characterization and immunomodulating activities of polysaccharide from Lentinus edodes. Int Immunopharmacol. 2005 May;5(5):811-20. Epub 2004 Dec 2.
  9. Nakazawa T, Kaneko S, Miyazaki Y, Jojima T, Yamazaki T, Katsukawa S, Shishido K. Basidiomycete Lentinula edodes CDC5 and a novel interacting protein CIPB bind to a newly isolated target gene in an unusual manner. Fungal Genet Biol. 2008 Jun;45(6):818-28. doi: 10.1016/j.fgb.2008.02.007. Epub 2008 Feb 29.
  10. Reverberi M, Fabbri AA, Zjalic S, Ricelli A, Punelli F, Fanelli C. Antioxidant enzymes stimulation in Aspergillus parasiticus by Lentinula edodes inhibits aflatoxin production. Appl Microbiol Biotechnol. 2005 Nov;69(2):207-15. Epub 2005 Nov 12.
  11. Okamoto T, Kodoi R, Nonaka Y, Fukuda I, Hashimoto T, Kanazawa K, Mizuno M, Ashida H. Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver. Biofactors. 2004;21(1-4):407-9.
  12. Sasidharan S, Aravindran S, Latha LY, Vijenthi R, Saravanan D, Amutha S. In vitro antioxidant activity and hepatoprotective effects of Lentinula edodes against paracetamol-induced hepatotoxicity. Molecules. 2010 Jun 23;15(6):4478-89. doi: 10.3390/molecules15064478.
  13. Watanabe A, Kobayashi M, Hayashi S, Kodama D, Isoda K, Kondoh M, Kawase M, Tamesada M, Yagi K. Protection against D-galactosamine-induced acute liver injury by oral administration of extracts from Lentinus edodes mycelia. Biol Pharm Bull. 2006 Aug;29(8):1651-4.
  14. de Lima PL, Delmanto RD, Sugui MM, da Eira AF, Salvadori DM, Speit G, Ribeiro LR. Letinula edodes (Berk.) Pegler (Shiitake) modulates genotoxic and mutagenic effects induced by alkylating agents in vivo. Mutat Res. 2001 Sep 20;496(1-2):23-32.
  15. Love KM, Barnett RE, Holbrook I, Sonnenfeld G, Fujii H, Sun B, Peyton JC, Cheadle WG. A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis. J Trauma Acute Care Surg. 2013 Jun;74(6):1411-8. doi: 10.1097/TA.0b013e31829215b1.
  16. Wu H, Tao N, Liu X, Li X, Tang J, Ma C, Xu X, Shao H, Hou B, Wang H, Qin Z. Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells. PLoS One. 2012;7(12):e51751. doi: 10.1371/journal.pone.0051751. Epub 2012 Dec 18.
  17. Xu X, Yan H, Zhang X. Structure and immuno-stimulating activities of a new heteropolysaccharide from Lentinula edodes. J Agric Food Chem. 2012 Nov 21;60(46):11560-6. doi: 10.1021/jf304364c. Epub 2012 Nov 12.
  18. Zheng R, Jie S, Hanchuan D, Moucheng W. Characterization and immunomodulating activities of polysaccharide from Lentinus edodes. Int Immunopharmacol. 2005 May;5(5):811-20. Epub 2004 Dec 2.
  19. Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14. doi: 10.3978/j.issn.2305-5839.2014.01.05.
  20. Love KM, Barnett RE, Holbrook I, Sonnenfeld G, Fujii H, Sun B, Peyton JC, Cheadle WG. A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis. J Trauma Acute Care Surg. 2013 Jun;74(6):1411-8. doi: 10.1097/TA.0b013e31829215b1.
  21. Jung BG, Lee JA, Lee BJ. Immunoprophylactic effects of shiitake mushroom (Lentinula edodes) against Bordetella bronchiseptica in mice. J Microbiol. 2012 Dec;50(6):1003-8. doi: 10.1007/s12275-012-2365-1. Epub 2012 Dec 30.
  22. Bisen PS, Baghel RK, Sanodiya BS, Thakur GS, Prasad GB.Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem. 2010;17(22):2419-30.
  23. Lee JY, Kim JY, Lee YG, Rhee MH, Hong EK, Cho JY. Molecular mechanism of macrophage activation by Exopolysaccharides from liquid culture of Lentinus edodes. J Microbiol Biotechnol. 2008 Feb;18(2):355-64.
  24. Shuvy M, Hershcovici T, Lull-Noguera C, Wichers H, Danay O, Levanon D, Zolotarov L, Ilan Y. Intrahepatic CD8(+) lymphocyte trapping during tolerance induction using mushroom derived formulations: a possible role for liver in tolerance induction. World J Gastroenterol. 2008 Jun 28;14(24):3872-8.
  25. Lee HH, Lee JS, Cho JY, Kim YE, Hong EK. Structural characteristics of immunostimulating polysaccharides from lentinus edodes. J Microbiol Biotechnol. 2009 May;19(5):455-61.
  26. Zheng R, Jie S, Hanchuan D, Moucheng W. Characterization and immunomodulating activities of polysaccharide from Lentinus edodes. Int Immunopharmacol. 2005 May;5(5):811-20. Epub 2004 Dec 2.
  27. Liu M, Li J, Kong F, Lin J, Gao Y. Induction of immunomodulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes. Immunopharmacology. 1998 Nov;40(3):187-98.

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