Other Names: Melissa officinalis

Melissa officinalis, commonly known as lemon balm, is a calming perennial herb that belongs to the mint family. It is native to southern Europe and the Mediterranean region and has been taken by many people for thousands of years in order to promote natural defenses that protect the healthy cell and DNA from numerous harmful invaders, toxins, free radicals and oxidative stress. Documentation dates back to the Middle Ages showing that Melissa officinalis was taken to support healthy digestion as well as promote relaxation, a pleasant mood and sound sleep.

Modern uses for lemon balm include its ability to help the immune system naturally protect the body. Furthermore, it promotes healthy responses to situations that may cause anxiety and stress. It also supports the body’s natural ability to eliminate toxic chemicals before they are able to enter into the bloodstream. Therefore, lemon balm is useful for supporting enhanced overall well-being and mental health.

Studies on Lemon Balm:

  1. Zeraatpishe A, Oryan S, Bagheri MH, Pilevarian AA, Malekirad AA, Baeeri M, Abdollahi M. Effects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation. Toxicol Ind Health. 2011 Apr;27(3):205-12. doi: 10.1177/0748233710383889. Epub 2010 Sep 21.
  2. Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, Kras M, Scholz C, Sass M, Buchwald-Werner S. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014 Oct 30;6(11):4805-21. doi: 10.3390/nu6114805.
  3. Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.
  4. Andrew Scholey, Amy Gibbs, Chris Neale, Naomi Perry, Anastasia Ossoukhova, Vanessa Bilog, Marni Kras, Claudia Scholz, Mathias Sass, and Sybille Buchwald-Werner. Anti-Stress Effects of Lemon Balm-Containing Foods. Nutrients. 2014 Nov; 6(11): 4805–4821.
  5. Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.
  6. Akbar Zeraatpishe, Shahrbano Oryan, Mohammad Hadi Bagheri, Ali Asghar Pilevarian, Ali Akbar Malekirad, Maryam Baeeri, and Mohammad Abdollahi. Effects of Melissa officinalis L.on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation. Toxicology and Industrial Health 27(3) 205–212.

Other research:

  1. Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20(2):96-102.
  2. Miron TL, Herrero M, Ibáñez E. Enrichment of antioxidant compounds from lemon balm (Melissa officinalis) by pressurized liquid extraction and enzyme-assisted extraction. J Chromatogr A. 2013 May 3;1288:1-9. doi: 10.1016/j.chroma.2013.02.075. Epub 2013 Mar 4.
  3. Petrovic V, Marcincak S, Popelka P, Simkova J, Martonova M, Buleca J, Marcincakova D, Tuckova M, Molnar L, Kovac G. The effect of supplementation of clove and agrimony or clove and lemon balm on growth performance, antioxidant status and selected indices of lipid profile of broiler chickens. J Anim Physiol Anim Nutr (Berl). 2012 Dec;96(6):970-7. doi: 10.1111/j.1439-0396.2011.01207.x. Epub 2011 Aug 10.
  4. Spiridon I, Colceru S, Anghel N, Teaca CA, Bodirlau R, Armatu A. Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania. Nat Prod Res. 2011 Oct;25(17):1657-61. doi: 10.1080/14786419.2010.521502. Epub 2011 Jun 27.
  5. Lara MS, Gutierrez JI, Timón M, Andrés AI. Evaluation of two natural extracts (Rosmarinus officinalis L. and Melissa officinalis L.) as antioxidants in cooked pork patties packed in MAP. Meat Sci. 2011 Jul;88(3):481-8. doi: 10.1016/j.meatsci.2011.01.030. Epub 2011 Feb 4.
  6. Dias MI, Barros L, Sousa MJ, Ferreira IC. Systematic comparison of nutraceuticals and antioxidant potential of cultivated, in vitro cultured and commercial Melissa officinalis samples. Food Chem Toxicol. 2012 Jun;50(6):1866-73. doi: 10.1016/j.fct.2012.03.057. Epub 2012 Mar 22.
  7. Martins EN, Pessano NT, Leal L, Roos DH, Folmer V, Puntel GO, Rocha JB, Aschner M, Ávila DS, Puntel RL. Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice. Brain Res Bull. 2012 Jan 4;87(1):74-9. doi: 10.1016/j.brainresbull.2011.10.003. Epub 2011 Oct 15.
  8. García-Iñiguez de Ciriano M, Larequi E, Rehecho S, Calvo MI, Cavero RY, Navarro-Blasco I, Astiasarán I, Ansorena D. Selenium, iodine, omega-3 PUFA and natural antioxidant from Melissa officinalis L.: a combination of components from healthier dry fermented sausages formulation. Meat Sci. 2010 Jun;85(2):274-9. doi: 10.1016/j.meatsci.2010.01.012. Epub 2010 Jan 14.
  9. Pereira RP, Fachinetto R, de Souza Prestes A, Puntel RL, Santos da Silva GN, Heinzmann BM, Boschetti TK, Athayde ML, Bürger ME, Morel AF, Morsch VM, Rocha JB. Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus. Neurochem Res. 2009 May;34(5):973-83. doi: 10.1007/s11064-008-9861-z. Epub 2008 Oct 14.
  10. Marongiu B, Porcedda S, Piras A, Rosa A, Deiana M, Dessì MA. Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora. Phytother Res. 2004 Oct;18(10):789-92.
  11. Hohmann J, Zupkó I, Rédei D, Csányi M, Falkay G, Máthé I, Janicsák G. Protective effects of the aerial parts of Salvia officinalis, Melissa Officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med. 1999 Aug;65(6):576-8.
  12. Blomhoff R. [Antioxidants and oxidative stress]. [Article in Norwegian] Tidsskr Nor Laegeforen. 2004 Jun 17;124(12):1643-5.
  13. Luño V, Gil L, Olaciregui M, Jerez RA, de Blas I, Hozbor F. Antioxidant effect of lemon balm (Melissa officinalis) and mate tea (Ilex paraguensys) on quality, lipid peroxidation and DNA oxidation of cryopreserved boar epididymal spermatozoa. Andrologia. 2014 Nov 8. doi: 10.1111/and.12370. [Epub ahead of print]
  14. Zeraatpishe A, Oryan S, Bagheri MH, Pilevarian AA, Malekirad AA, Baeeri M, Abdollahi M. Effects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation. Toxicol Ind Health. 2011 Apr;27(3):205-12. doi: 10.1177/0748233710383889. Epub 2010 Sep 21.
  15. Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20(2):96-102.
  16. Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13
  17. Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, Kras M, Scholz C, Sass M, Buchwald-Werner S. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014 Oct 30;6(11):4805-21. doi: 10.3390/nu6114805
  18. Feliú-Hemmelmann K, Monsalve F, Rivera C. Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser. Int J Clin Exp Med. 2013 Jun 26;6(6):444-51. Print 2013.
  19. Bayat M, Azami Tameh A, Hossein Ghahremani M, Akbari M, Mehr SE, Khanavi M, Hassanzadeh G. Neuroprotective properties of Melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo. Daru. 2012 Oct 3;20(1):42. doi: 10.1186/2008-2231-20-42.
  20. Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. Eur J Med Res. 2004 Sep 29;9(9):423-31.
  21. Drozd J, Anuszewska E. The effect of the Melissa officinalis extract on immune response in mice. Acta Pol Pharm. 2003 Nov-Dec;60(6):467-70.
  22. Hur YG, Yun Y, Won J. Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. J Immunol. 2004 Jan 1;172(1):79-87.

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These statements have not been evaluated by the FDA. This product is not intended to prevent, treat, cure, or diagnose any disease. Information on this site is for educational purposes only. It is not medical advice. Consult a physician if you are seeking medical advice or have a medical problem.

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