BioPerine® is a standardized black pepper fruit extract that enhances the absorption of other nutrients which support various processes in the body. Therefore, black pepper fruit extract helps the body maintain good health.

According to the BioPerine® manufacturer, “The subtle, yet potent properties of BioPerine® have been measured in several clinical studies with healthy volunteers in the U.S. These studies measured the absorption of three distinct categories of products. The categories evaluated with and without BioPerine® were fat-soluble (beta-carotene), water-soluble (vitamin B6) and a mineral (selenium, in the form of selenomethionine). Gastrointestinal absorption of all the studied nutrients, as measured by amounts present in the blood, increased dramatically when administered with BioPerine® as compared to the control group receiving the nutrient alone.”

Black Pepper Fruit has been repeatedly shown through research to help:

  • Support immune system functions through its strong antioxidant activity
  • Aid natural defenses that protect healthy cells and DNA from oxidative stress

Interestingly, research emphasizes that one of the main benefits of black pepper fruit is its ability to increase the absorption of additional nutrients that the body needs. For instance, optimal levels of vitamin B6, C and selenium are often observed and maintained in the body when black pepper fruit is taken regularly. This mineral also aids the absorption of nutrients in the gastrointestinal tract, which enhances metabolism and this biological process is associated with better weight support. Therefore, supplements that contain black pepper extract help the body gets the most out of the nutrients it receives.

Studies on Black Pepper Fruit:

  1. Chuchawankul S, Khorana N, Poovorawan Y. Piperine inhibits cytokine production by human peripheral blood mononuclear cells. Genet Mol Res. 2012 Mar 14;11(1):617-27. doi: 10.4238/2012.March.14.5.
  2. Meghwal M, Goswami TK. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. doi: 10.1002/ptr.4972. Epub 2013 Apr 29.
  3. Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. 2000 Feb;11(2):109-13.
  4. Vladimir Badmaev MD, PhD, Muhammed Majeed PhD, Edward P. Norkus PhD. Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutrition Research, Vol. 19. No. 3, pp. 381-388, 1999.

Other research:

  1. Misharina TA, Terenina MB, Krikunova NI. [Antioxidant properties of essential oils]. [Article in Russian] Prikl Biokhim Mikrobiol. 2009 Nov-Dec;45(6):710-6.
  2. Gülçin I. The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. Int J Food Sci Nutr. 2005 Nov;56(7):491-9.
  3. Parim B, Harishankar N, Balaji M, Pothana S, Sajjalaguddam RR. Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats. Pharm Biol. 2015 Apr 9:1-11. [Epub ahead of print]
  4. Bagheri H, Abdul Manap MY, Solati Z. Antioxidant activity of Piper nigrum L. essential oil extracted by supercritical CO₂ extraction and hydro-distillation. Talanta. 2014 Apr;121:220-8. doi: 10.1016/j.talanta.2014.01.007. Epub 2014 Jan 16.
  5. Agbor GA, Akinfiresoye L, Sortino J, Johnson R, Vinson JA. Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Food Chem. 2012 Oct 1;134(3):1354-9. doi: 10.1016/j.foodchem.2012.03.030. Epub 2012 Mar 23.
  6. Agbor GA, Vinson JA, Sortino J, Johnson R. Antioxidant and anti-atherogenic activities of three Piper species on atherogenic diet fed hamsters.Exp Toxicol Pathol. 2012 May;64(4):387-91. doi: 10.1016/j.etp.2010.10.003. Epub 2010 Oct 28.
  7. Kapoor IP, Singh B, Singh G, De Heluani CS, De Lampasona MP, Catalan CA. Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum). J Agric Food Chem. 2009 Jun 24;57(12):5358-64. doi: 10.1021/jf900642x.
  8. Karthikeyan J, Rani P. Enzymatic and non-enzymatic antioxidants in selected Piper species. Indian J Exp Biol. 2003 Feb;41(2):135-40.
  9. Vijayakumar RS, Surya D, Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 2004;9(2):105-10.
  10. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 2007;47(8):735-48.
  11. Choi BM, Kim SM, Park TK, Li G, Hong SJ, Park R, Chung HT, Kim BR. Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells. J Nutr Biochem. 2007 Sep;18(9):615-22. Epub 2007 Apr 5.
  12. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4.
  13. Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP. Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats. Cell Mol Neurobiol. 2014 Apr;34(3):403-8. doi: 10.1007/s10571-014-0025-1. Epub 2014 Jan 9.
  14. Doucette CD, Greenshields AL, Liwski RS, Hoskin DW. Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways. Toxicol Lett. 2015 Apr 2;234(1):1-12. doi: 10.1016/j.toxlet.2015.01.020. Epub 2015 Feb 2.
  15. Kumar A, Sharma N. Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pestic Biochem Physiol. 2015 Mar;119:16-27. doi: 10.1016/j.pestbp.2015.03.003. Epub 2015 Mar 10.
  16. Kumar A, Sasmal D, Sharma N. Immunomodulatory role of piperine in deltamethrin induced thymic apoptosis and altered immune functions. Environ Toxicol Pharmacol. 2015 Mar;39(2):504-14. doi: 10.1016/j.etap.2014.12.021. Epub 2015 Jan 8.
  17. Chuchawankul S, Khorana N, Poovorawan Y. Piperine inhibits cytokine production by human peripheral blood mononuclear cells. Genet Mol Res. 2012 Mar 14;11(1):617-27. doi: 10.4238/2012.March.14.5.

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These statements have not been evaluated by the FDA. This product is not intended to prevent, treat, cure, or diagnose any disease. Information on this site is for educational purposes only. It is not medical advice. Consult a physician if you are seeking medical advice or have a medical problem.

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