Zinc acetate is the most bioavailable form of the zinc mineral and it is essential for good health because a zinc deficiency is associated with various health problems. Animals and plants typically have adequate levels of zinc but it is not naturally produced by the human body and therefore must be acquired from outside sources.

Zinc is important for numerous processes in the body, which include proper immune system responses, detoxification, and cellular function. Optimal cellular health is an essential way to experience healthier skin. Extensive research also explains that taking zinc helps the body maintain healthy hormonal levels that are essential for proper daily functioning and stamina. It also promotes metabolism, which is often associated with better weight support.

Zinc has been found to be very helpful due to its ability to promote immune system functions such as the activation of T-lymphocytes; these are specific white blood cells that help protect cells from foreign invaders and toxins. In a similar fashion, it helps the body’s natural defenses protect healthy cells and DNA from oxidative stress and free radicals. Interestingly, many people experience optimal health just by adding zinc to their diets.

Studies on Zinc:

  1. Sharif R, Thomas P, Zalewski P, Fenech M. Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Mol Nutr Food Res. 2015 Jun;59(6):1200-12. doi: 10.1002/mnfr.201400784. Epub 2015 May 13.
  2. Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, Kalkan G. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014 Jun;33(2):99-102. doi: 10.3109/15569527.2013.808656. Epub 2013 Jul 5.
  3. Chuanxi Cai, Peihui Lin, Hua Zhu, Jae-Kyun Ko, Moonsun Hwang, Tao Tan, Zui Pan, Irina Korichneva and Jianjie Ma. Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes. May 29, 2015 The Journal of Biological Chemistry, 290, 13830-13839.
  4. Sharif R, Thomas P, Zalewski P, Fenech M. Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Mol Nutr Food Res. 2015 Jun;59(6):1200-12. doi: 10.1002/mnfr.201400784. Epub 2015 May 13.

Other research:

  1. Liu Z, Wu X, Zhang T, Guo J, Gao X, Yang F, Xing X. Effects of Dietary Copper and Zinc Supplementation on Growth Performance, Tissue Mineral Retention, Antioxidant Status, and Fur Quality in Growing-Furring Blue Foxes (Alopex lagopus). Biol Trace Elem Res. 2015 Jun 2. [Epub ahead of print]
  2. Gowanlock DW, Mahan DC, Jolliff JS, Hill GM. Evaluating the influence of National Research Council levels of copper, iron, manganese, and zinc using organic (Bioplex) minerals on resulting tissue mineral concentrations, metallothionein, and liver antioxidant enzymes in grower-finisher swine diets. J Anim Sci. 2015 Mar;93(3):1149-56. doi: 10.2527/jas.2014-8173.
  3. Negahdary M, Chelongar R, Zadeh SK, Ajdary M. The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition. Adv Biomed Res. 2015 Mar 25;4:69. doi: 10.4103/2277-9175.153893. eCollection 2015.
  4. Dkhil MA, Al-Quraishy S, Wahab R. Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum. Int J Nanomedicine. 2015 Mar 11;10:1961-8. doi: 10.2147/IJN.S79944. eCollection 2015.
  5. Sharif R, Thomas P, Zalewski P, Fenech M. Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Mol Nutr Food Res. 2015 Jun;59(6):1200-12. doi: 10.1002/mnfr.201400784. Epub 2015 May 13.
  6. Younesi S, Parsian H, Hosseini SR, Noreddini H, Mosapour A, Bijani A, Halalkhor S. Dyshomeostasis of Serum Oxidant/Antioxidant Status and Copper, Zinc, and Selenium Levels in Elderly Physically Disabled Persons: an AHAP-Based Study. Biol Trace Elem Res. 2015 Feb 13. [Epub ahead of print]
  7. Drakou M, Birmpa A, Koutelidakis AE, Komaitis M, Panagou EZ, Kapsokefalou M. Total antioxidant capacity, total phenolic content and iron and zinc dialyzability in selected Greek varieties of table olives, tomatoes and legumes from conventional and organic farming. Int J Food Sci Nutr. 2015 Mar;66(2):197-202. doi: 10.3109/09637486.2014.979320. Epub 2015 Jan 13.
  8. Wan C, Zhang M, Fang Q, Xiong L, Zhao X, Hasunuma T, Bai F, Kondo A. The impact of zinc sulfate addition on the dynamic metabolic profiling of Saccharomyces cerevisiae subjected to long term acetic acid stress treatment and identification of key metabolites involved in the antioxidant effect of zinc. Metallomics. 2015 Feb;7(2):322-32. doi: 10.1039/c4mt00275j.
  9. Ebrahimiasl S, Zakaria A, Kassim A, Basri SN. Novel conductive polypyrrole/zinc oxide/chitosan bionanocomposite: synthesis, characterization, antioxidant, and antibacterial activities. Int J Nanomedicine. 2014 Dec 30;10:217-27. doi: 10.2147/IJN.S69740. eCollection 2015.
  10. Wang C, Li B, Wang B, Xie N. Degradation and antioxidant activities of peptides and zinc-peptide complexes during in vitro gastrointestinal digestion. Food Chem. 2015 Apr 15;173:733-40. doi: 10.1016/j.foodchem.2014.10.066. Epub 2014 Oct 18.
  11. Pandurangan M, Veerappan M, Kim DH. Cytotoxicity of zinc oxide nanoparticles on antioxidant enzyme activities and mRNA expression in the cocultured C2C12 and 3T3-L1 cells. Appl Biochem Biotechnol. 2015 Feb;175(3):1270-80. doi: 10.1007/s12010-014-1351-y. Epub 2014 Nov 8.
  12. Muthuraman P, Ramkumar K, Kim DH. Analysis of dose-dependent effect of zinc oxide nanoparticles on the oxidative stress and antioxidant enzyme activity in adipocytes. Appl Biochem Biotechnol. 2014 Dec;174(8):2851-63. doi: 10.1007/s12010-014-1231-5. Epub 2014 Sep 19.
  13. Malakooti J, Sandoval R, Memark VC, Dudeja PK, Ramaswamy K. Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G653-63. Epub 2005 Jun 23.
  14. Kang JL, Pack IS, Hong SM, Lee HS, Hah JS, Nam W, Leonard S, Castranova V. Zinc tetrakis(N-methyl-4′-pyridyl) porphyrinato is an effective inhibitor of stimulant-induced activation of RAW 264.7 cells. Toxicol Appl Pharmacol. 2001 Apr 15;172(2):140-9.
  15. Akuzawa N, Kurabayashi M, Ohyama Y, Arai M, Nagai R. Zinc finger transcription factor Egr-1 activates Flt-1 gene expression in THP-1 cells on induction for macrophage differentiation. Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):377-84.
  16. Ooi TC, Mohammad NH, Sharif R. Zinc carnosine protects against hydrogen peroxide-induced DNA damage in WIL2-NS lymphoblastoid cell line independent of poly (ADP-Ribose) polymerase expression. Biol Trace Elem Res. 2014 Dec;162(1-3):8-17. doi: 10.1007/s12011-014-0153-y. Epub 2014 Oct 19.
  17. Singh M, Odeniyi DT, Apostolov EO, Savenka A, Fite T, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage. Am J Physiol Renal Physiol. 2013 Oct 1;305(7):F1022-30. doi: 10.1152/ajprenal.00532.2012. Epub 2013 Jul 3.
  18. Santon A, Albergoni V, Santovito G, Sturniolo GC, Irato P. Relationship between metallothionine and zinc in the protection against DNA damage in zinc-treated Long-Evans Cinnamon rat liver. Eur J Histochem. 2004 Jul-Sep;48(3):317-20.
  19. Yang M, Yang Y, Zhang Z, Hao X, Zheng S, Zhong L, Fan A, Xu W. [Study of zinc in protecting sperm from sodium nitroprusside damage]. [Article in Chinese] Zhonghua Nan Ke Xue. 2004 Jul;10(7):530-2, 537.
  20. Record IR, Jannes M, Dreosti IE. Protection by zinc against UVA- and UVB-induced cellular and genomic damage in vivo and in vitro. Biol Trace Elem Res. 1996 Summer;53(1-3):19-25.
  21. Adebayo OL, Sandhir R, Adenuga GA. Protective roles of selenium and zinc against postnatal protein-undernutrition-induced alterations in Ca(2+)-homeostasis leading to cognitive deficits in Wistar rats. Int J Dev Neurosci. 2015 Jun;43:1-7. doi: 10.1016/j.ijdevneu.2015.03.007. Epub 2015 Mar 17.
  22. Li Y, Zheng Y, Qian J, Chen X, Shen Z, Tao L, Li H, Qin H, Li M, Shen H. Preventive effects of zinc against psychological stress-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats. Biol Trace Elem Res. 2012 Jun;147(1-3):285-91. doi: 10.1007/s12011-011-9319-z. Epub 2012 Jan 25.
  23. Takeda A, Ando M, Kanno S, Oku N. Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation. Neurotoxicology. 2009 Jul;30(4):712-7. doi: 10.1016/j.neuro.2009.05.009. Epub 2009 Jun 6.
  24. Carroll D, Ring C, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl). 2000 Jun;150(2):220-5.
  25. Pizent A, Jurasović J, Pavlović M, Telisman S. Serum copper, zinc and selenium levels with regard to psychological stress in men. J Trace Elem Med Biol. 1999 Jul;13(1-2):34-9.
  26. Tochio N, Umehara T, Nakabayashi K, Yoneyama M, Tsuda K, Shirouzu M, Koshiba S, Watanabe S, Kigawa T, Sasazuki T, Shirasawa S, Yokoyama S. Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT. J Struct Funct Genomics. 2015 Jun;16(2):55-65. doi: 10.1007/s10969-015-9196-3. Epub 2015 Mar 24.
  27. Guzman-Rivero M, Verduguez-Orellana A, Montaño K, Cloetens L, Rojas E, Åkesson B, Sejas E. The immune response in patients with cutaneous leishmaniasis and the influence of zinc supplementation. Biomed Pharmacother. 2015 Feb;69:56-62. doi: 10.1016/j.biopha.2014.11.006. Epub 2014 Nov 15.
  28. Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, Kalkan G. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014 Jun;33(2):99-102. doi: 10.3109/15569527.2013.808656. Epub 2013 Jul 5.
  29. Abd El-Wahab A, Radko D, Kamphues J. High dietary levels of biotin and zinc to improve health of foot pads in broilers exposed experimentally to litter with critical moisture content. Poult Sci. 2013 Jul;92(7):1774-82. doi: 10.3382/ps.2013-03054.
  30. Veenemans J, Schouten LR, Ottenhof MJ, Mank TG, Uges DR, Mbugi EV, Demir AY, Kraaijenhagen RJ, Savelkoul HF, Verhoef H. Effect of preventive supplementation with zinc and other micronutrients on non-malarial morbidity in Tanzanian pre-school children: a randomized trial. PLoS One. 2012;7(8):e41630. doi: 10.1371/journal.pone.0041630. Epub 2012 Aug 3.
  31. Bath-Hextall FJ, Jenkinson C, Humphreys R, Williams HC. Dietary supplements for established atopic eczema. Cochrane Database Syst Rev. 2012 Feb 15;2:CD005205. doi: 10.1002/14651858.CD005205.pub3.
  32. Richelle M, Sabatier M, Steiling H, Williamson G. Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium. Br J Nutr. 2006 Aug;96(2):227-38.
  33. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med. 1998 Dec;18(4):673-85.

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